The men from Hillsborough will return for duty on Monday 4 July, and after some local preparation matches, will host a prestigious pre-season fixture when Portuguese champions Benfica visit Hillsborough on Wednesday 20 July.
Sheffield Wednesday will then fly out to Faro the following day where they will be put through their paces in the warm weather environment.
Primeira Liga team Nacional will provide the opposition on Sunday 24 July at the Estádio Albufeira Municipal stadium, with match details to be confirmed.
Sheffield Wednesday came within one game of gaining promotion to the Premier League last season, eventually losing to Yorkshire rivals Hull City in the Championship play-off final.
In preparation for their Super Cup showdown against Sporting e Braga on 7 August, Benfica have in addition to their match against Sheffield Wednesday, also agreed to play another Championship team.
Derby County will be providing the opposition in a mini-tournament being staged at the Algarve Stadium between 14 and 16 July, with the Rams taking the field against the Portuguese champions on 16 July.
To date, no Premier League clubs have confirmed any pre-season fixtures for Portugal this summer.