The action gets underway as newly promoted CD Aves entertain Sporting on Sunday at 6pm followed by Vitória de Setúbal at home to Moreirense at 8.15pm.
A big night for SC Portimonense fans on Monday as the Segunda Liga champions come up against Boavista FC (Porto) in Portimão, kick-off 5pm.
CD Feirense v. Tondela is at 7pm followed by Rio Ave and Belenenses at 9pm.
Last season’s runners-up FC Porto are at home to Estoril on Wednesday night at 7pm followed by Benfica entertaining SC Braga at the Estadio de Luz; kick-off 9pm.
The last game of the opening round is next Thursday when Vitória de Guimarães play GD Chaves at 9pm.