Already through are group winners Atlético Madrid, Barcelona, Leicester City and Monaco.
They are joined by Arsenal, Bayer Leverkusen, Bayern Munich, Borussia Dortmund, Juventus, Manchester City, Paris Saint-Germain and Real Madrid.
Benfica must win against Napoli to be sure of reaching the lucrative knockout stages although a draw or defeat would do, if Besiktas fail to beat Dynamo Kiev.
Leicester have won their group so may rest a few players as they travel to play Porto at the Dragão Stadium.
København have a head-to-head advantage over Porto on away goals so will come second if they win against Brugge and Porto do not beat Leicester.
Real Madrid and Barcelona are well used to ticking over at over two-and-a-half goals per game, but this season there is a new kid on the block putting them both in the shade.
Monaco thumped Marseille 4-0 last Saturday to take their season tally to 43 in fourteen outings in France’s top flight.
That is better than three goals a game and superior to what any other side has managed in Europe’s top six leagues this season.
Managed by former Sporting boss Leonardo Jardim, the team is firing on all cylinders with Portuguese internationals João Moutinho and Bernardo Silva in impressive form.
In the Europa League. SC Braga will qualify for the round of sixteen if Konyaspor (Turkey) beat Gent (Belgium) but if the Belgian side win then Braga will have to beat Shakhtar Donetsk at The Quarry.
A daunting task given that ‘Os Arsenalistas’ have lost their previous five games against the Ukrainian side and in the process conceded thirteen goals whilst only scoring one in reply.