But the Portuguese national team will once again be hoping to prove they can win games without their inspirational captain as they did last Sunday in their 3-0 win over Norway.
Portugal is currently ranked eighth in the FIFA rankings, three ahead of England, but the result of the match will be less important than the two sides preparing for the 2016 European championships which kick-off on Friday 10 June.
Portugal will before finalising their preparations for France on 8 June when they host Estonia in Lisbon.
Portugal’s Euro campaign kicks off 14 June against Iceland, with Hungary and Austria also in their qualifying group.
The game kicks at 7.45pm and will be shown on open channel TVI in Portugal and on ITV on UK channels.